Understanding Gamma Delta T Cell Function in the Gastrointestinal Tract

2021 PhD scholarship opportunity

Supervisor: Dr Lisa Mielke

Laboratory: Mucosal Immunity and Cancer

 

Our research focuses on identifying new immune targets that can be explored to develop novel therapeutics to treat stomach and colon cancers. We use mouse models and patient samples to understand the organ-specific functions of immune cells. We study heterogeneous populations of T cells, known as intraepithelial lymphocytes that are distinct in their frequency and function across different organs of the gastrointestinal tract (GI). Our preliminary studies have shown that one population, known as gamma delta T cells, plays a protective role in colon cancer.

In this project we will use single-cell RNA sequencing, flow cytometry and multiplexed fluorescent immunohistochemistry technologies to understand the function of gamma delta T cells in mouse models of cancer and patient samples.

 

Discover more about La Trobe University’s PhD program and this opportunity or contact our Student Co-ordinator via students@onjcri.org.au

Application deadlines:
International students – 30 September 2020
Domestic students – 31 October 2020