Making cancer cells lose a game of hide-and-seek

In his latest publication in Cell Reports, Dr Conor Kearney and his team unveil groundbreaking findings that significantly contribute to our fight against cancer.

“We have conducted a world-first epigenetic-targeted CRISPR screen to identify the ways by which cancer cells hide from our immune system,” said Dr Kearney.

“We identified a protein that can shield cancer cells from being attacked by immune cells. More importantly, we demonstrate that by stopping the function of this protein with a drug which is currently in clinical trials, we now make these cancer cells more visible to attack by our immune cells.”

“This is potentially a game-changer in the world of immunotherapy, especially for patients battling solid cancers where responses are often elusive.”