Our research focus

Human cancers harbour defects in processes that inhibit or enhance tumour growth, so-called tumour suppressor and oncogenes. Importantly, these abnormalities render the tumour cells resistant to many therapies.

Our research is focused on understanding how cancers develop and finding new therapy approaches, including targeted drugs as well as immune therapies to treat these cancers.

We aim to identify novel genes involved in the development of normal and malignant haematopoiesis. We are using in vivo CRISPR approaches to systematically identify new candidate genes, with the ultimate goal of using these targets as novel anti-cancer therapies.

We have recently also started to understand the mechanisms of therapy resistance in cancers and how we can overcome this by reducing the fitness of the cancer cells or enhancing immune therapies using different CRISPR approaches.

Recent publications

Cell death & Differentiation

Combined absence of TRP53 target genes ZMAT3, PUMA and p21 cause a high incidence of cancer in mice

DOI: 10.1038/s41418-023-01250-w

18 December 2023

View abstract
CELL DEATH & DIFFERENTIATION

Genome-wide CRISPR screening identifies a role for ARRDC3 in TRP53-mediated responses

DOI: 10.1038/s41418-023-01249-3

14 December 2023

View abstract
Stem Cell Reports

Integration of xeno-free single-cell cloning in CRISPR-mediated DNA editing of human iPSCs improves homogeneity and methodological efficiency of cellular disease modeling

DOI: 10.1016/j.stemcr.2023.10.013

12 December 2023

View abstract

Our team

Meet our researchers

  • Prof Marco Herold - Head, Blood Cancer and Immunotherapy Laboratory & Chief Executive Officer Publications
  • Andrew Kueh - CRISPR Platform Lead
  • Lin Tai - Laboratory Manager
  • Kieran Lau - CRIPSR Microinjection Lead
  • Yexuan Deng - Postdoctoral Research Fellow
  • Goknur Giner - Postdoctoral Research Fellow
  • Christina Koenig - Postdoctoral Research Fellow
  • Eddie Lamarca - Postdoctoral Research Fellow
  • Emily Lelliott - Postdoctoral Research Fellow
  • Maggie Potts - Postdoctoral Research Fellow
  • Geraldine Healey - Senior Research Assistant
  • Jonathan Cebon - Honorary
  • Amali Cooray - PhD Student
  • Wei Jin - PhD Student
  • Gaoyuan Wang - PhD Student