Tumour Progression and Heterogeneity Laboratory

Follow tumour progression using cellular tracking, multi-omic analysis and patient samples

The spread of cancer cells to distant sites of the body, a process called  ‘metastasis’, is difficult to predict and treat. To study this mechanism, our laboratory is developing new strategies to label individual cancer cells collected from patient tumours, using tags or ‘barcodes’. Using innovative technologies such as single cell sequencing and imaging, we can track the fate of multiple subpopulations of cells and their contribution to metastasis in specific organs, such as the brain. We are particularly interested in identifying new predictive biomarkers of distant recurrence, and new therapeutic strategies to prevent or stop disease progression.  

Study the effect of different microenvironments or ‘niches’ on the survival of cancer cells

Previous studies have shown that many cancer cells can escape from the primary tumours, but only a small fraction can survive in distant organs. Using patient samples and preclinical models, our laboratory is investigating how non-malignant cells from vital organs such as the lungs, liver and brain, influence the survival of cancer cells and how these mechanisms can be therapeutically exploited.

Test new drugs in advanced models of metastatic breast cancer

Working closely with clinicians and patient advocates, our laboratory aims to accelerate the development of therapies that prevent and stop metastasis. Through innovative technologies, we evaluate new ways to optimise the effectiveness of drugs currently approved in cancer therapy, and develop next-generation therapies to target the most aggressive cancer cells.